CTNNB1 mouse monoclonal antibody, clone UMAB15, 100 uL/ 30 uL
R$10.441,33
| Imunógeno | Proteína recombinante humana de comprimento total de CTNNB1 humano (NP_001895) produzida na célula HEK293T. |
| Aplicações | WB 1:500, IHC 1:100, IF 1:100, FLOW 1:100 |
| Aplicações2 | WB, IF, FC |
| Resumo | A proteína codificada por este gene faz parte de um complexo de proteínas que constituem as junções aderentes (AJs). Os AJs são necessários para a criação e manutenção das camadas de células epiteliais, regulando o crescimento celular e a adesão entre as células. A proteína codificada também ancora o citoesqueleto de actina e pode ser responsável por transmitir o sinal de inibição de contato que faz com que as células parem de se dividir quando a camada epitelial estiver completa. Por fim, essa proteína se liga ao produto do gene APC, que sofre mutação na polipose adenomatosa do cólon. Mutações neste gene são uma causa de câncer colorretal (CCR), pilomatricoma (PTR), meduloblastoma (MDB) e câncer de ovário. Três variantes de transcrição que codificam a mesma proteína foram encontradas para este gene. |
| Formulação | PBS (pH 7.3) contendo 1% BSA, 50% glicerol e 0.02% azida sódica. |
| Purificação | Purificado a partir de fluidos de ascite de camundongo por cromatografia de afinidade |
| Isotipo | IgG1 |
| Reatividade | Humano, Camundongo, Rato, Macaco |
| Hospedeiro | Camundongo |
| Tamanho | 85.3 kDa |
| Tipo | UltraMAB |
| Concentração | 0.97 mg/ml |
Article Snippet
“Mouse monoclonal anti-human Bcl9 (BMR00368; 2.0 μg/ml ) was a gift from Bio Matrix Research Inc. (Nagareyama, Chiba, Japan) and rabbit polyclonal anti-human Bcl9 (ab37305; 5.0 μg/ml) was purchased from Abcam (Cambridge, MA, USA) [ , ].. Mouse monoclonal anti-β-catenin (CTNNB1, UM500015; 1.33 μg/ml) was purchased from OriGene (Rockville, MD, USA).. Horseradish peroxidase (HRP)-conjugated goat anti-mouse IgG (AP308P; 10.0 μg/ml) and HRP-conjugated goat anti-rabbit IgG (AP307P; 10.0 μg/ml) antibodies were from Millipore (Temecula, CA, USA).”
Tumor β-catenin expression is associated with immune evasion in non-small cell lung cancer with high tumor mutation burden
Satoshi Muto, Yuki Ozaki, …, Hiroyuki Suzuki
“e Chemical Industries Ltd.) in 100% methanol. Following incubation with 5% skimmed milk in PBS for 30 min at room temperature, the sections were incubated overnight at 4°C with primary monoclonal antibodies against β-catenin (1:100; cat. no. UMAB15; OriGene Technologies, Inc.), CD8 (1:50; cat. no. C8/144B; Agilent Technologies, Inc.), or CD11c (1:200; cat. no. 2F1C10; ProteinTech Group, Inc.). The primary antibody was then detected using biotinylated secondary anti-mouse IgG (1:400; cat. no. E041”
PURE ANDROGEN-PRODUCING ADRENAL TUMOR: CLINICAL FEATURES AND PATHOGENESIS.
Anli Tong, Jun Jiang, …, Xueyan Wu
“Abstract: Pure androgen-secreting adrenal tumors (PASATs) are extremely rare, most reports involving only a single case. This study examined 9 cases of PASAT, with an attempt to characterize its clinical features and to explore the pathogenesis.”
A Novel Phenotype of Familial Hyperaldosteronism Type III: Concurrence of Aldosteronism and Cushing’s Syndrome
Anli Tong, Guanghua Liu, …, Jun Cai
“Abstract: To date, all the familial hyperaldosteronism type III (FH-III) patients reported presenting with typical primary aldosteronism (PA), without showing other adrenal hormone abnormalities. This study characterized a novel phenotype of FH-III and explored the possible pathogenesis. A male patient presented with severe hypertension and hypokalemia at the age of 2 years and developed Cushing’s syndrome at 20 years. He was diagnosed with PA and Cushing’s syndrome on the basis of typical biochemical findings. He had massive bilateral adrenal hyperplasia and underwent left adrenalectomy”
Avaliações
Não há avaliações ainda.