Menu fechado

MGMT mouse monoclonal antibody, clone UMAB52, 100 uL/ 30 uL

R$8.063,10

Imunógeno Proteína recombinante humana de comprimento total de MGMT humano (NP_002403) produzida em E. coli.
Aplicações IHC 1:50, IF 1:100
Aplicações2 IHC
Resumo
Formulação PBS (pH 7.3) contendo 1% BSA, 50% glicerol e 0.02% azida sódica.
Purificação Purificado a partir de fluidos de ascite de camundongo por cromatografia de afinidade
Isotipo IgG1
Reatividade Humano, Macaco
Hospedeiro Camundongo
Tamanho
Tipo UltraMAB
Concentração 2.99mg/ml
SKU: UM800006 Categoria: Tag:
Int J Cancer    |    Dec 11, 2018    |    PubMed ID: 30289977    |    Read Article
Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide.
Tor-Christian Johannessen, Md Mahdi Hasan-Olive, …, Lars Prestegarden
Abstract: Glioblastoma multiforme (GBM) has a poor prognosis with an overall survival of 14-15 months after surgery, radiation and chemotherapy using temozolomide (TMZ). A major problem is that the tumors acquire resistance to therapy. In an effort to improve the therapeutic efficacy of TMZ, we performed a genome-wide RNA interference (RNAi) synthetic lethality screen to establish a functional gene signature for TMZ sensitivity in human GBM cells. We then queried the Connectivity Map database to search for drugs that would induce corresponding changes in gene expression. By this approach we identified several potential pharmacological sensitizers to TMZ, where the most potent drug was the established antipsychotic agent Thioridazine, which significantly improved TMZ sensitivity while not demonstrating any significant toxicity alone”

Avaliações

Não há avaliações ainda.

Seja o primeiro a avaliar “MGMT mouse monoclonal antibody, clone UMAB52, 100 uL/ 30 uL”

O seu endereço de e-mail não será publicado.